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Ambien, Lunesta, Sonata: What Are the 'Z Meds' for Sleep?

Medically reviewed by Carmen Pope, BPharm. Last updated on March 8, 2024.

By Ernie Mundell HealthDay Reporter

FRIDAY, March 8, 2024 -- Ambien, Lunesta, Sonata: Millions of bleary-eyed Americans turn to this class of so-called "Z-drugs" to get restful sleep.

But how do these drugs work, and do they come with risks?

Experts at the U.S. Food and Drug Administration have issued an advisory to boost awareness about the meds.

All of these medications -- generically known as zolpidem (Ambien, Ambien CR, Edluar and Zolpimist), eszopiclone (Lunesta) and zaleplon (Sonata) -- work by putting the brakes on brain activity, allowing you to drift off to sleep.

But the FDA warns that Z drugs also come with risks, most notably upping your odds for "complex sleep behaviors" -- things like sleepwalking, sleep driving, sleep cooking or even taking other medicines.

"The FDA has received reports of people taking these insomnia medicines and accidentally overdosing, falling, being burned, shooting themselves and wandering outside in extremely cold weather, among other incidents," the agency noted.

You might not even recall any of these behaviors occurring once you reawaken, according to the FDA.

The onset of complex sleep behaviors tied to Z drug use is also unpredictable. For some, the behavior can begin after the first dose, while for others it might begin much later into use.

Many sleep medicines can also cause daytime drowsiness, so avoid driving and other hazardous tasks under those circumstances.

Some other tips for safe use of Z drugs:

SOURCE: U.S. Food and Drug Administration, health advisory, March 6, 2024

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2024 HealthDay. All rights reserved.

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